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KMID : 0359720210390010026
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Journal of the Korean Neurological Association
2021 Volume.39 No. 1 p.26 ~ p.39
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Low Doses of Baclofen Induced Nonconvulsive Status Epilepticus in a Patient with Chronic Kidney Disease
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Kim Soo-Hyun
Kim Su-Min
Kim Hyun-Ji
Kim Hyung-Ho
Yun Ji-Young
Lee Jung-Hwa
Kim Geon-Ha
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Abstract
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Baclofen, a gamma-aminobutyric acid B agonist, is frequently used in the treatment of various neurologic diseases including spasticity, dystonia and trigeminal neuralgia. This drug usually acts at the presynaptic motor neuron to induce an antispastic response. Oral baclofen toxicity is extremely rare, but is often reported to affect patients with renal disease. Here, we report a patient with chronic kidney disease who was treated with relatively low doses of baclofen (5 mg twice per day) and experienced nonconvulsive status epilepticus.
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KEYWORD
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Status epilepticus, Baclofen, Chronic kidney disease
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